All-In with Chamath, Jason, Sacks & Friedberg
Hosted by Chamath Palihapitiya, David Friedberg, David Oliver Sacks & Jason McCabe Calacanis · 70 decoded episodes · newest Oct 2, 2026
Industry veterans, degenerate gamblers & besties Chamath Palihapitiya, Jason Calacanis, David Sacks & David Friedberg cover all things economic, tech, political, social & poker.
Episodes 70
- Oct 2, 2026 · 1h 22mWhite House AI accord tests self-regulation against alarmismThe discussion connects voluntary AI governance and America’s compute race to economic confidence, household costs, and the 2026 political landscape.
- Sep 30, 2026 · 53 minJake Paul and the Chainsmokers turn attention into operating leverageThe episode tests whether fame creates durable value only when paired with execution, domain expertise, and disciplined capital allocation.
- Sep 28, 2026 · 51 minDaniel Ek takes Spotify’s playbook into preventive healthcareThe conversation examines whether earlier detection, richer health data, and better incentives can make preventive care more affordable and effective.
- Sep 26, 2026 · 1h 34mOpen models pressure AI valuations and frontier economicsThe episode weighs whether cheaper open models, consumer agents, and regulation could overturn the business models and political assumptions driving the AI boom.
- Sep 23, 2026 · 26 minBending Spoons turns acquisitions into a technology operating systemLuca Ferrari offers a detailed case for building a large European technology company by combining disciplined acquisitions with centralized engineering and talent.
- Sep 23, 2026 · 56 minCalifornia Republicans test an anti-establishment comebackThe conversation examines whether conservative candidates can overcome California’s one-party political system, ballot operations, and entrenched policy incentives.
- Sep 22, 2026 · 18 minBoom Supersonic bets aviation can break its speed ceilingThe episode examines whether Boom can turn supersonic passenger travel from a historical exception into a commercially viable service.
- Sep 21, 2026 · 23 minUnconventional AI bets on new hardware to break the energy wallAs conventional AI systems demand ever more energy, Naveen Rao argues that changing the underlying computing architecture may be unavoidable.
- Sep 20, 2026 · 24 minAppLovin turns a near-collapse into an advertising machineThe conversation shows how specialized data, deep learning, and disciplined execution can challenge the scale advantages of Google and Meta.
- Sep 19, 2026 · 38 minGurley challenges institutions to confront COVID’s unanswered questionsThe discussion connects unresolved pandemic origins with failures in journalism, public leadership, prevention, and trust.
- Sep 18, 2026 · 39 minIsaacman pushes NASA toward a lunar proving groundThe debate captures a consequential choice for NASA: spread resources across competing priorities or concentrate them on lunar infrastructure, Mars preparation, and strategic competition with China.
- Sep 18, 2026 · 33 minIndependent reporting challenges California’s accountability gapThe episode examines how costly public projects, alleged service fraud, and restrictions on reporting test the limits of institutional oversight.