This Week in Startups
Hosted by Jason McCabe Calacanis & Lon Harris · 45 decoded episodes · newest Oct 8, 2026
Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.
Episodes 45
- Aug 17, 2026 · 1h 25mBittensor co-founder Jacob Steeves outlines the future of decentralized artificial intelligenceThis episode provides a deep dive into the mechanics and economic incentives of Bittensor, highlighting how blockchain technology can be used to decentralize artificial intelligence development.
- Aug 15, 2026 · 1h 20mAnthropic rumored to target massive trillion dollar valuation in upcoming IPOThis episode unpacks how massive AI valuations and physical automation are reshaping both public markets and labor-intensive industries like construction.
- Aug 12, 2026 · 1h 4mStartups deploy hardware automation to slash shipping costs and expand healthcareAutomation is moving beyond software as physical robotics and specialized kiosks begin to restructure the economics of local retail logistics and basic healthcare delivery.
- Aug 11, 2026 · 1h 20mZuckerberg uses AI manifesto to clear path for data center expansionTech giants are shifting their strategies, using public relations to secure physical infrastructure while rewriting the rules of creator monetization.
- Aug 7, 2026 · 1h 18mAI integration divides tech earnings as floating nuclear reactors eye data centersAs AI development demands unprecedented levels of power and data, the tech sector is forcing a massive rethink of both global energy infrastructure and national security boundaries.
- Aug 5, 2026 · 1h 13mVCs dissect Airtable acquisition and the new reality of startup valuationsThis episode provides a rare look inside the VC playbook as firms adapt to lower startup valuations, secondary market pressures, and internal AI automation.
- Aug 3, 2026 · 1h 2mHow Bespoke faked its AI chatbot to win major enterprise clientsThis episode demonstrates how founders can use creative hacks to validate technology and how Japan's demographic crisis is fueling a new wave of robotics and automation startups.
- Jul 31, 2026 · 1h 15mStartups build curation engines to teach artificial intelligence human tasteAs generative AI floods the internet with generic content, teaching machine models human-like taste and aesthetic judgment has become the next major frontier in technology.
- Jul 27, 2026 · 44 minCultivated meat startup reaches profitability by pivoting to cosmetics marketAs the global cell-cultured meat sector struggles with high costs and regulatory hurdles, this pivot offers a viable blueprint for biotechnology survival.
- Jul 24, 2026 · 45 minQuantum computing startups pivot to global integration to bypass hardware bottlenecksAs quantum hardware matures, the race to build stable qubits is shifting from academic theory to a global commercial and geopolitical scramble with massive cryptographic implications.
- Jul 22, 2026 · 1h 12mLongevity startup bypasses Silicon Valley to build in JapanThe episode highlights how international regulatory environments and alternative funding structures are challenging Silicon Valley's monopoly on deep-tech innovation.
- Jul 17, 2026 · 47 minSoftware startups target surgical automation and fractional real estate investingAs software eating the world enters its physical phase, startups are bypassing expensive custom hardware to automate surgery and fractionalize real estate.