CATIE study
Workby Jeffrey A. Lieberman, Thomas S. Stroup, Joseph P. McEvoy, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators · 2005
Heard in 1 episode across 1 show since Sep 2026
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) was a large, NIMH-funded randomized clinical trial comparing the effectiveness, tolerability, and practical outcomes of antipsychotic medications in people with chronic schizophrenia. Its primary phase-1 paper found that most participants discontinued treatment, with olanzapine showing the longest time to discontinuation but greater metabolic concerns, while perphenazine performed similarly to several newer antipsychotics.
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What experts have said about CATIE study
1 statement · 1 negative
Sixty-seven to eighty-two percent of CATIE participants discontinued treatment.
“Between 67 and 82% of the patients, depending on which drug they were on, dropped out of the trial”
Open the episode · #502 – Psychiatry, Insane Asylums, Mental Illness, ECT, Lobotomies, Freud & JungListen at 3:16:42
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
Episodes
1 episode featuring CATIE study, newest first
