Cortico-basal ganglia-thalamo-cortical loop
TopicHeard in 1 episode across 1 show since Jul 2026
The cortico-basal ganglia-thalamo-cortical loop (CBGTC loop) is a system of neural circuits in the brain that connects the cerebral cortex, basal ganglia, and thalamus. This pathway plays a crucial role in regulating motor control, cognitive processes, and emotional behavior. Dysregulation within this loop is strongly associated with movement disorders like Parkinson's disease, as well as psychiatric conditions such as obsessive-compulsive disorder (OCD) and ADHD.
Episodes
First heard
Expert statements
Episodes per month
Public PodLume episodes featuring it, over the last year.
Show the data
| Month | Episodes |
|---|---|
| Nov 2025 | 0 |
| Dec 2025 | 0 |
| Jan 2026 | 0 |
| Feb 2026 | 0 |
| Mar 2026 | 0 |
| Apr 2026 | 0 |
| May 2026 | 0 |
| Jun 2026 | 0 |
| Jul 2026 | 1 |
| Aug 2026 | 0 |
| Sep 2026 | 0 |
| Oct 2026 | 0 |
What experts have said about Cortico-basal ganglia-thalamo-cortical loop
2 statements · 2 negative
The corticostriatothalamic loop and its dysfunction are thought to underlie OCD
“That loop, this corticostriatothalamic loop. Corticostriatothalamic loop is the circuit thought to underlie ocd and dysfunction in that circuit is what's thought to underlie ocd”
Open the episode · Essentials: The Science & Treatment of Obsessive Compulsive Disorder (OCD)Listen at 11:12
OCD provocation studies show increased activity in the corticostriatal thalamic loop
“what lights up when I say lights up. What. What sorts of brain regions are more metabolically active, more blood flow, more neural activity? Well, it's this particular corticostriatal thalamic loop”
Open the episode · Essentials: The Science & Treatment of Obsessive Compulsive Disorder (OCD)Listen at 12:50
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
Episodes
1 episode featuring Cortico-basal ganglia-thalamo-cortical loop, newest first
