What podcasts say about Pendleton Read Montague, Jr.
Every statement, with the speaker, the exact quote and the moment it was said.
What Pendleton Read Montague, Jr. has said on podcasts
31 statements · 13 positive · 7 negative · 2 mixed · 9 neutral
Dopamine fluctuations control learning.
“It's very clearly a learning signal, number one. So dopamine fluctuations high and low, control learning.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 4:37
Dopamine encodes successive prediction changes during ongoing learning.
“And dopamine is encoding those signals.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 9:10
Temporal-difference learning algorithms occur across species, including humans.
“An algorithm based on that is installed in bee brains, sea slug brains, all the way up to human brains.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 10:50
DeepMind used the dopamine-linked learning algorithm to create a world-champion Go program.
“That algorithm that I just described with my hands waving is the same thing that David Silver and the DeepMind guys did when they made the world champion go playing program.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 22:36
Aggregated prediction errors can signal motivation and desired effort.
“Those prediction errors are perfect signals for deciding how motivated you should be, how much should you want a thing by measuring across those kinds of signals.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 27:07
Clinical Parkinson’s disease typically involves loss of 70–75% of brainstem dopamine neurons.
“By the time you show up with symptoms in the doctor's office, you've lost 70 to 75% of your dopamine neurons in your brain stem.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 32:17
Parkinson’s disease produces a flattened ability to distinguish action values.
“And the Parkinson's state is sort of like a flat value function. You can't really see differential value in things.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 34:06
Parkinson’s disease is characterized as an active freezing state.
“So I've always thought about Parkinson's as an active freezing disease.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 34:35
Dopamine and other neuromodulators stabilize and sustain brain states.
“It's very clear. Dopamine and the other neuromodulators are involved in stabilizing and sustaining brain states.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 37:00
Dopamine-raising ADHD medications may narrow and stabilize thought sequences.
“I suspect, if you made me guess, that it's stabilizing brain states and thought sequences in a way that's narrow and it doesn't divert.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 39:48
Exploratory behavioral states promote searching for new information and opportunities.
“And the sort of ADD guys are the explorers. They're looking for new information, new nectar sources, et cetera.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 41:52
Humans differ in their built-in balance between exploration and focused exploitation.
“This distribution of abilities is built into all of us, but it's different across us.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 42:40
Artificial networks require constraints to balance goal pursuit and exploration.
“You have to balance that and sometimes you have to impose constraints to make that happen in an artificial network.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 47:19
Effort may improve learning by slowing processing and behavior.
“When you have to do effort, it's easier to learn something because it slows you down.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 52:27
Resistance can become rewarding, including pathologically in anorexia.
“It feels good to resist and they do it pathologically.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 59:26
Serotonin promotes readiness for active waiting.
“Serotonin tells you to get ready to wait.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:03:23
Dopamine and serotonin show opposing fluctuations during learning and motivation.
“The theme that emerges from that is dopamine and serotonin are opponent to one another.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:04:39
Severe hunger can shift rodent dopamine signaling toward punishment prediction errors.
“If you make a rodent hungry, then you can show that dopamine will encode something like punishment prediction errors, not reward prediction errors.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:12:23
Excessive dopamine stimulation can raise expectations beyond most natural rewards.
“If you look at it, on the average, it resets expectations where very few, if any, natural events can exceed them.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:20:02
An SSRI study found serotonin enters dopamine terminals through dopamine transporter pathways.
“This paper by John Danny in 2005 showed it goes into the dopamine system.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:28:39
SSRI-related serotonin redistribution may impair positive learning and reinforce negative events.
“You would have a hard time learning about positive things. You might also register negative events as being rewarding and you'd learn yourself into a kind of depression that way.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:29:17
Nasal neurotransmitter recordings resemble expected midbrain dopamine and serotonin signals.
“What we see in the nasal recordings looks very much like exactly what we would expect if we were recording from the neurons in the midbrain.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:35:43
Breathing cycles modulate the amplitude of neurotransmitter fluctuations.
“The amplitude of the neurotransmitter fluctuations follows the inhale, exhale, cycles.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 1:58:35
Dopamine activates mitochondrial energy production.
“Dopamine turns on mitochondria.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:03:36
Sleep supports computational erasure, homeostasis, and physiological recovery.
“And a lot of it's about erasure and homeostasis and recovery.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:06:21
Dopamine plays a critical role in interval timing and temporal anticipation.
“There's a whole literature in rodents called the interval timing literature, where you teach an animal to anticipate something at a particular time in the future, in the near future, few seconds. And dopamine plays a critical role in that.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:08:14
Neurotransmitter-informed neural networks will become dominant in future neurobiology.
“That kind of thing is going to dominate neurobiology coming up.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:22:26
Blocking dopamine receptors reduces hallucinations in schizophrenia.
“If you block dopamine receptors, you don't hear voices anymore.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:27:34
Sufficient levodopa can induce auditory hallucinations in some people without Parkinson’s or schizophrenia.
“If you take L dopa and you don't have Parkinson's and you don't have schizophrenia, I can find a dose where you will start to hear voices.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:27:37
AI will improve understanding of how expectations are represented and updated.
“That's what AI is going to help us do in the next 20 years.”
Open the episode · How Dopamine & Serotonin Shape Decisions, Motivation & Learning | Dr. Read MontagueListen at 2:29:19
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.