The a16z Show
Hosted by Ben Horowitz, Marc Andreessen & Stephanie White · 59 decoded episodes · newest Oct 8, 2026
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
Episodes 59
- Sep 14, 2026 · 51 minOpenAI frames computer-using agents as the next AGI thresholdThe discussion links AGI’s definition to sustained computer-based work while confronting the infrastructure, security, and governance needed to deploy it safely.
- Sep 13, 2026 · 24 minWorld models turn 3D space into AI infrastructureThe conversation frames spatially grounded world models as a bridge between generative media, robotics, games, and physical intelligence.
- Sep 12, 2026 · 1h 18mAI loops could expand ambition, not eliminate human agencyThe conversation offers a practical and optimistic framework for understanding how AI may reshape work, consumer products, and startup strategy.
- Sep 11, 2026 · 38 minTiny startups face big policy blind spotsThe episode connects the survival of two- and three-person startups to the regulatory, economic, and local conditions that shape where they build.
- Sep 10, 2026 · 49 minAI pushes venture beyond software and toward bigger power lawsThe episode argues that AI is widening the investable economy while making access, timing, and portfolio construction more consequential.
- Sep 9, 2026 · 40 minIndependent evaluations race to keep pace with AI modelsAs models move into agents, enterprise workflows, and policy decisions, outdated or self-reported benchmarks can obscure both capability and risk.
- Sep 8, 2026 · 1h 5mAI models push mathematical discovery beyond human persistenceThe episode examines whether reasoning models are becoming collaborators that can generate, test, and extend ideas in areas where mathematics remains poorly understood.
- Sep 7, 2026 · 8 minOpen source faces an uphill fight against concentrated AI powerThe episode tests whether open source can counter advantages in data, compute, coding agents, and large data centers before incumbents become unassailable.
- Sep 6, 2026 · 28 minAI could help healthcare leapfrog legacy softwareHealthcare’s slow technology adoption may become an advantage if AI can widen access to medical expertise while lowering costs and personalizing care.
- Sep 5, 2026 · 31 minAaron Levie makes the case for open AI modelsThe debate over open weights now reaches beyond model access to national competitiveness, enterprise economics, and who captures value as AI becomes cheaper.
- Sep 4, 2026 · 45 minAtlas turns sparse views into navigable worldsThe conversation examines whether new-view prediction can become a foundational capability for spatial intelligence, from creative tools to robotics.
- Sep 3, 2026 · 1h 1mAffirm founders explain why tiny payments become giant marketsThe conversation connects payment infrastructure, merchant economics, and emerging AI interfaces to explain where the next major fintech opportunities may form.