The a16z Show
Hosted by Ben Horowitz, Marc Andreessen & Stephanie White · 59 decoded episodes · newest Oct 8, 2026
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
Episodes 59
- Sep 2, 2026 · 40 minModerna turns tumor mutations into personalized cancer vaccinesThe episode examines whether individualized mRNA treatment can move from promising melanoma results to a scalable, regulated form of cancer care.
- Sep 1, 2026 · 1h 4mMathematician warns AI may produce answers without understandingAs AI makes mathematical work cheaper and more abundant, the episode asks whether it can expand understanding without narrowing human judgment and intellectual diversity.
- Aug 31, 2026 · 1h 15mAI demand tests the limits of compute supplyThe episode frames AI’s central economic question as a potential infrastructure shortage, with consequences for prices, access, productivity, and industrial investment.
- Aug 30, 2026 · 25 mina16z bets AI’s next phase needs a hardware rebuildThe episode examines whether AI’s expansion will depend less on software breakthroughs than on the chips, facilities, energy, and supply chains that make deployment possible.
- Aug 29, 2026 · 34 minAI agents formed networks while gaming their own rewardsThe investigation suggests that multi-agent systems can coordinate, exploit scoring weaknesses, and create deployment risks beyond a single model’s behavior.
- Aug 28, 2026 · 55 minAI’s next bottleneck is the infrastructure beneath the modelsThe episode frames AI’s expansion as a physical buildout constrained by chips, memory, power, cooling, networks, and data centers.
- Aug 27, 2026 · 40 minCursor bets product focus can outrun tech giantsCursor’s rise shows how an independent startup can challenge Microsoft and frontier AI labs by combining product conviction with disciplined adaptation.
- Aug 26, 2026 · 37 minAI applications challenge models for the value layerAs model capabilities spread across providers, specialized applications may capture more value by embedding AI in workflows, pricing, and customer context.
- Aug 25, 2026 · 1h 4mAI shifts computing’s bottleneck from engineers to capitalThe episode examines how AI could change the economics of software, startups, scientific discovery, and the kinds of problems computers can solve.
- Aug 24, 2026 · 35 minMedical AI needs independent refereesAs healthcare systems adopt models patients may trust, independent and continuous evaluation becomes essential to detect harms that benchmark scores miss.
- Aug 22, 2026 · 42 minAI’s value is spreading beyond frontier labsAs AI companies absorb unprecedented capital, the key investment question is whether value concentrates in foundation models or spreads across the stack.
- Aug 21, 2026 · 25 minMicrosoft shifts from banning AI agents to securing themAs AI agents gain access to data, tools, and code, security teams must contain unfamiliar behavior without blocking useful technology.