APOE4 gene
TopicHeard in 1 episode across 1 show since Aug 2026
APOE4 (Apolipoprotein E4) is a major genetic variant of the APOE gene, which provides instructions for making a protein that helps carry cholesterol and other fats in the bloodstream. It is the strongest genetic risk factor for late-onset Alzheimer's disease, with individuals carrying one or two copies of the allele having a significantly increased likelihood of developing the condition. Beyond Alzheimer's, the APOE4 allele is also associated with an increased risk of cardiovascular disease and cognitive decline.
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| Nov 2025 | 0 |
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| Jan 2026 | 0 |
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| Aug 2026 | 1 |
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What experts have said about APOE4 gene
6 statements · 4 negative · 2 neutral
APOE4 is among the strongest genetic risk factors for Alzheimer’s disease.
“The APOE4 gene is one of the strongest risk factors of getting Alzheimer's disease.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 1:20
Carrying APOE4 does not make Alzheimer’s disease inevitable.
“But it is not a foregone conclusion that you're going to get it.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 1:27
One APOE4 copy raises Alzheimer’s risk two to threefold.
“when you have a copy of the APOE4 gene, it raises your risk by two to three times.”
Open the episode · Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain NowListen at 2:06
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
Episodes
1 episode featuring APOE4 gene, newest first
