Sex hormone-binding globulin
TopicHeard in 1 episode across 1 show since Jul 2026
Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to androgens and estrogens, regulating their bioavailability in the bloodstream. It is produced primarily by the liver and released into the general circulation. When produced by the Sertoli cells in the seminiferous tubules of the testis, it is referred to as androgen-binding protein (ABP).
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| Month | Episodes |
|---|---|
| Nov 2025 | 0 |
| Dec 2025 | 0 |
| Jan 2026 | 0 |
| Feb 2026 | 0 |
| Mar 2026 | 0 |
| Apr 2026 | 0 |
| May 2026 | 0 |
| Jun 2026 | 0 |
| Jul 2026 | 1 |
| Aug 2026 | 0 |
| Sep 2026 | 0 |
| Oct 2026 | 0 |
What experts have said about Sex hormone-binding globulin
3 statements · 1 positive · 1 negative · 1 neutral
Strict ketogenic diets and high stress are associated with elevated SHBG.
“People who are on a strict ketogenic diet have high SHBG. People who are under a lot of cortisol load, high stress, they have high SHBG.”
Open the episode · Best Peptides, Stem Cells, Testosterone & Exercise Hacks - Biohacking Roundtable - #1148Listen at 2:27:28
SHBG binds circulating androgens and estrogens.
“It is the protein that binds up all androgens and estrogens in the body.”
Open the episode · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle GillettListen at 1:29
High SHBG can increase DHT by reducing its metabolism.
“if your SHBG is very high, then your DHT can run higher because it's not metabolized”
Open the episode · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle GillettListen at 1:50
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
Episodes
1 episode featuring Sex hormone-binding globulin, newest first
