Yamanaka factors

Yamanaka factors

Topic

Heard in 1 episode across 1 show since Aug 2026

The Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc) are a group of four highly expressed transcription factors capable of reprogramming mature somatic cells back into pluripotent stem cells. Discovered by Japanese researcher Shinya Yamanaka in 2006, this breakthrough allows for the creation of induced pluripotent stem cells (iPSCs) without using embryonic tissue, earning Yamanaka the 2012 Nobel Prize in Physiology or Medicine.

Episodes

1
across 1 show

First heard

Aug 2026

Expert statements

1
1 negative

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Public PodLume episodes featuring it, over the last year.

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What experts have said about Yamanaka factors

1 statement · 1 negative

  1. David SinclairNegativeAug 24, 2026· Modern Wisdom

    The full Yamanaka-factor combination is dangerous in humans

    “If you just use what Professor Yamanaka used, it's not going to be very healthy. It's actually quite dangerous.”

    Listen at 2:45

    Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141

Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.

Episodes

1 episode featuring Yamanaka factors, newest first

Yamanaka factors · PodLume