What podcasts say about Nolan R. Williams
Every statement, with the speaker, the exact quote and the moment it was said.
What Nolan R. Williams has said on podcasts
35 statements · 26 positive · 5 negative · 2 mixed · 2 neutral
Depression is the world’s most disabling condition.
“Depression is the most disabling condition worldwide.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 0:56
The American Heart Association recognizes depression as a major coronary artery disease risk factor.
“the American Heart association added depression as the fourth major risk factor for coronary artery disease.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 1:11
Transcranial magnetic stimulation can decelerate heart rate.
“with transcranial magnetic stimulation, a form of brain stimulation, we can actually decelerate the heart rate.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 1:40
The heart appears to be the terminal organ of dorsolateral prefrontal cortex signaling.
“the heart very consistently seems to be the end organ of the dorsolateral prefrontal cortex.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 3:54
TMS is an especially promising approach for depression-related cognitive regulation.
“TMS is really interesting, actually.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 4:24
TMS restores left dorsolateral prefrontal control over the cingulate area.
“What we see with TMS over that region is that we just exogenously do the same sort of thing. We restore the governance of the left dorsolateral over the cingulate area.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 5:47
Greater left dorsolateral retiming produces a stronger antidepressant effect.
“the more of an antidepressant effect you have.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 6:10
Repeated TMS stimulation functions similarly to brain exercise.
“TMS is almost like exercise for the brain, right?”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 6:12
SSRIs improve depression and several anxiety-related disorders in some patients.
“SSRIs clearly work, you know, many, many meta analyses kind of proving that out”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 9:48
SSRIs do not produce therapeutic effects on the day treatment begins.
“they don't work immediately, right? So they don't work like the same day you start taking them.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 10:14
Depression is not caused by a congenital serotonin deficit or chemical imbalance.
“There's not a deficit of serotonin. You're not born with what people call a chemical imbalance.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 10:31
TMS can work without introducing serotonin into the brain.
“TMS works and there's no serotonin coming in or out of the brain.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 12:12
Psilocybin and ketamine are associated with circuit-level brain changes after the drugs leave the body.
“there are a lot of groups that are actually doing neuroimaging before and after, and they're able to see circuit level changes for something like psilocybin or ketamine long after the drug is gone”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 12:57
People with psychiatric illnesses can recover.
“People can get better.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 14:16
TMS and psychedelic treatments can restore normal mood within five days or less.
“people are actually in normal levels of mood for sustained periods of time within five days, within five or less days.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 14:22
MDMA and psilocybin appear to produce relatively long-lasting therapeutic effects for trauma-related phenomena.
“some new, like mdma, some that have been around for thousands of years, like psilocybin, seem to have a therapeutic effect that seems to be pretty long lasting for these phenomenon.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 16:57
One to several MDMA sessions appear to reduce PTSD symptoms.
“MDMA appears to, in one to a few MDMA sessions, have an anti PTSD effect”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 18:25
Approximately two-thirds of participants experienced clinically significant PTSD improvement.
“It's about 2/3 of people had a clinically significant change in their ptsd.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 19:13
MDMA-related PTSD improvements lasted years for some participants.
“it seemed to last for kind of in the years range for some people.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 19:25
A single ketamine infusion produces antidepressant effects lasting about one and a half weeks on average.
“with ketamine, which only on average lasts about a week and a half for a single infusion”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 19:32
Open-label psilocybin studies report improvement in roughly half to two-thirds of participants.
“it's closer to half to 2/3 of people end up getting better depending upon their level of treatment.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 20:09
Blinded psilocybin trials report improvement in approximately one-third of participants.
“In the blinded trials, it was more like a third or so of people.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 20:14
Psychedelics produce an overall decrease in brain activity.
“what they found is the opposite, right? There's kind of a, an overall decrease in the level of activity in the brain with psychedelics.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 22:01
Psychedelics increase global brain connectivity.
“the connectivity kind of global connectivity kind of increases.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 22:32
Psilocybin and TMS appear to share a convergent antidepressant mechanism.
“suggesting there's a convergent mechanism.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 23:38
Ibogaine appears exceptionally potent but carries unusually high risk because of cardiac effects.
“ibogaine is kind of both seemingly the most potent and most, seemingly to me at least most powerful psychedelic, but the one that has the most risk too, because it has a cardiac effect.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 26:10
Electrocardiogram screening can substantially reduce ibogaine-related cardiac risk.
“you can screen people out that have risk off of their electrocardiogram and reduce the risk quite a bit.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 26:27
If validated, psychedelic-assisted cognitive reexamination will likely be considered a psychiatric breakthrough.
“if it is true, then it's very likely that this will be seen as a breakthrough”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 28:56
Psychedelics such as ibogaine should not be used recreationally.
“these drugs can't be recreational drugs. They really shouldn't be recreational drugs.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 29:14
Ayahuasca appears to be safe based on available observations.
“it appears to be safe.”
Open the episode · Essentials: Psychedelics & Neurostimulation for Brain Rewiring | Dr. Nolan WilliamsListen at 33:11
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.