What podcasts say about David Sinclair
Every statement, with the speaker, the exact quote and the moment it was said.
What David Sinclair has said on podcasts
113 statements · 85 positive · 19 negative · 6 mixed · 3 neutral
Yamanaka-factor treatment safely reversed aging in a mouse
“we could reverse aging safely in an animal for the first time”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 1:47
The treatment works across many tissues in animals
“it's pretty much working in every part of the animal's body”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 2:15
Human trials are testing eye age reversal to improve or restore vision
“there are people getting their. Hopefully their age reversed in their eye to cure their blindness or at least improve their vision”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 2:22
The full Yamanaka-factor combination is dangerous in humans
“If you just use what Professor Yamanaka used, it's not going to be very healthy. It's actually quite dangerous.”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 2:45
ER100 easily treats macular degeneration and glaucoma in animals
“even macular degeneration, glaucoma, the two leading causes of blindness in the world, both of them are really, really easily treated by this new mechanism”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 5:00
The technology has reversed aging-related dysfunction in liver, brain, neurons, and joints
“the liver, motor neurons. So als, the brain has been reversed in aging, memory comes back, even joints”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 5:31
Aging is treatable or at least can be slowed
“we understand that it is very treatable, or at least slowable”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 9:21
Human aging reversal will eventually be demonstrated
“it's a matter of when, not if, that aging is reversible in humans”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 10:34
Sinclair’s lab has developed oral age-reversal compounds in mice
“we've made breakthroughs in turning it into a pill”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 12:01
The oral cocktail rejuvenates old mice’s memory and skin quality
“we see that they are rejuvenated in many ways, including not just their memory, but things like even their skin quality”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 12:17
The oral cocktail acts through epigenetic resetting
“we do have good evidence that the pill, let's call it the cocktail, does work through this epigenetic thing”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 13:33
Human lifespan ultimately has no biological upper limit
“ultimately there is no upper limit to human life”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 14:07
The first person to reach age 150 has already been born
“the first person to live to 150 is already alive”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 14:49
People should prioritize longevity to benefit from future technologies
“I think anyone that doesn't focus on their longevity might miss the boat”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 21:37
Metformin, rapamycin, senolytics, and GLP-1 agonists may improve longevity
“Then there's drugs, which, some of which may work. So that's metformin, rapamycin, some senolytics, and probably GLP1 receptor agonists”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 22:16
Eating less frequently and somewhat less improves longevity
“if you restrict how often you eat and to some extent how much you eat, you get longevity benefits”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 23:43
The idea that breakfast is the most important meal is marketing
“I believe one of those companies, Kellogg's perhaps, but this is, you know, it's all marketing”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 24:12
Beginners should start fasting by skipping one meal and drinking liquids
“I would suggest skipping one meal and replacing it with a lot of liquids”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 33:23
No prospective placebo-controlled human trial proves calorie restriction extends lifespan
“there's no proof”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 36:50
Calorie restriction extended lifespan in the disputed monkey study
“they came to the conclusion that yes, it did extend lifespan”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 37:30
Time-restricted feeding substantially extended mice’s lifespan
“the group that ate within that window lived substantially longer than the ones that ate continuously”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 40:28
High branched-chain amino acid intake shortens animal lifespan
“when you give animals a lot of these branch chain amino acids, they live shorter than if you give them less”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 41:56
Higher mTOR activity is associated with shorter animal lifespan
“animals that have active MTOR live shorter than those that have less active mtor”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 43:58
Longevity exercise should combine weightlifting, balance training, and aerobic conditioning
“the best health is a combination of weightlifting muscle is good for hormones. It's good for not breaking bones when you get older. Balance is important. And then the other One is aerobic. VO2 max.”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 44:41
Insufficient or poor-quality sleep harms metabolism
“If you're not getting quality sleep or sleeping for that long, it's going to affect your metabolism”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 47:52
NMN improves health and extends lifespan in old mice, especially females
“NMN is very good for the health of old mice and can extend the lifespan of mice, particularly females”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 56:06
Blocking resveratrol’s target eliminates its health and lifespan benefits in mice
“resveratrol doesn't make the mouse healthier anymore. It doesn't live longer.”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 58:16
Exercise or supplementation that raises NAD benefits humans
“raising NAD levels in humans, either by exercise and or by supplementation is good for you”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 1:02:15
The FDA currently permits NMN sales in the United States
“The FDA I believe says it's okay to have NMN on sale now”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 1:04:40
Baby aspirin may benefit people with elevated lipoprotein(a)
“there's a group of people, for example, that where it does make sense to take baby aspirin”
Open the episode · “Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair - #1141Listen at 1:05:46
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.
What others have said about David Sinclair
1 statement · 1 positive
Reversing an aging-related genomic mechanism could extend human lifespan.
“if David Sinclair is correct, and I think he is, if they can figure out a way to somehow or another access whatever part of the human genome allows us to age or causes us to age and reverse that or change that.”
Open the episode · #2545 - Jesse MichelsListen at 2:40:07
Statements are attributed to the speaker as said on the episode and reflect their view at the time, not PodLume's. They are not advice.